Genetic Origin of Osseous Metaplasia of the Endometrium: A Case Series

Osseous metaplasia of the endometrium is the presence of mature and immature bone tissue inside the endometrial cavity. We present a case series of three women who presented with various complaints of vaginal discharge and menstrual abnormalities. On hysteroscopy, bone fragments were extracted. Histopathological study of the bone tissue was supportive of osseous metaplasia. We performed a DNA analysis of the bone and compared it to the maternal genotype. We found a complete match between the patient and bone genotype, thus supporting that the bone originates from the patient.