Rapid detection of β-lactamase activity using the rapid Amp NP test
This work reports on a totally novel diagnostic technique, the Rapid Amp NP test for the identification of amoxicillin/ampicillin resistance in bacteria that are sources of non-complicated urinary tract infections. Those preliminary results obtained with cultured bacteria are promising. We believe its future use may contribute to reconsider aminopenicillins as a first line therapy for treating UTI infections. The corresponding patent of this test obtained both for the United States and Europe may contribute to its further industrialization.
Authors
- Camille Tinguely (ORCID: https://orcid.org/0009-0005-0509-0126)
- Nicolas Helsens (ORCID: https://orcid.org/0000-0001-8902-0486)
- Patrice Nordmann (ORCID: https://orcid.org/0000-0002-1343-1622)
- Nicolas Kieffer (ORCID: https://orcid.org/0000-0002-2672-1127)
- Gilbert Greub (ORCID: https://orcid.org/0000-0001-9529-3317)
- Laurent Poirel (ORCID: https://orcid.org/0000-0001-5160-5286)
Institutions
- University of Fribourg (CH)
- Institut Pasteur de Lille (FR)
- University of Lausanne (CH)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1128/spectrum.00782-24
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Université de Fribourg