Preliminary evaluation of the effect of partially hydrogenated 3-acetylisocoumarin derivatives on the cancer cells growth
In different conditions, from 3-acetyl-1H-isochromen-1-one three partial reduction products were obtained, namely 3-(1-hydroxyethyl)-1H-isochromen-1-one, 3-(1-hydroxyethyl)isochroman-1-one, and 3-ethylisochroman-1-one. The influence of two products with an alcohol fragment, as well as 4-hydroxy-1,2,3,4-tetrahydro-6H-benzo[c]chromen-6-one, on the growth of cancer cells was investigated through One Doses Full NCI 60 Cell Panel Assay. The only one significant effect was found: 3-(1-hydroxyethyl)-1H-isochromen-1-one practically stops the growth of CCRF-CEM cell lines (Leukemia)
Authors
- Olga V. Shablykina (ORCID: https://orcid.org/0000-0002-5362-0831)
- Oleh V. Shablykin (ORCID: https://orcid.org/0000-0001-6810-9860)
- Ilona Tarasiuk
Institutions
- Taras Shevchenko National University of Kyiv (UA)
- Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar (UA)
Publication Details
- Journal
- Ukrainica Bioorganica Acta
- Published
- 2024-12-30
- DOI
- https://doi.org/10.15407/bioorganica2024.02.033
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Enamine
- National Cancer Institute