Synthesis and study of antifungal activity of aromatic aldehyde 1,3-thiazol-2-yl hydrazones
A number of 1,3-thiazol-2-yl hydrazones of aromatic aldehydes were synthesized and tested for antifungal activity. It was found two promising compounds: 2-[(1Z)-[2-(4-methyl-1,3-thiazol-2-yl)hydrazin-1-ylidene]methyl]pyridine has MIC of 8 μg/ml against Cryptococcus neoformans and MIC of 16 μg/ml against Candida albicans and 4-[(1Z)-{2-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazin-1-ylidene}methyl]-2,6-dimethoxy-phenol has MIC of 0.5 μg/ml against Cryptococcus neoformans, respectively
Authors
- S. S. Tarnavskiy (ORCID: https://orcid.org/0000-0001-9656-0405)
- S. M. Yarmoluk (ORCID: https://orcid.org/0000-0002-5898-6103)
- Volodymyr G. Bdzhola (ORCID: https://orcid.org/0000-0003-0315-450X)
- С. С. Лукашов (ORCID: https://orcid.org/0000-0002-8664-4004)
- Volodymyr V. Voitiuk
Institutions
- Institute of Molecular Biology and Genetics (UA)
Publication Details
- Journal
- Ukrainica Bioorganica Acta
- Published
- 2024-12-30
- DOI
- https://doi.org/10.15407/bioorganica2024.02.037
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- University of Queensland
- National Academy of Sciences of Ukraine