Quantitative Protein Expression of Antibody–Drug Conjugate Targets in EGFR Mutated and Wild-type Non–Small Cell Lung Cancer
ADC targets are highly expressed in NSCLC, implying that the benefit from these agents may be broad. Benefit from these therapies may go beyond mutation status, and fully quantitative approaches may help select patients for ADC targeting. Intertarget correlation may provide an insight on the underlying signaling pathways and/or treatment-related resistant mechanisms. In the future, quantitative immunofluorescence may be a valuable tool to select ADC treatment sequence. See related commentary by Hirsch, p. 2550.
Authors
- Liam Scott (ORCID: https://orcid.org/0000-0002-6114-6324)
- Ioannis P. Trontzas (ORCID: https://orcid.org/0000-0003-3706-9995)
- Sneha Burela (ORCID: https://orcid.org/0000-0003-0287-0336)
- Thazin Nwe Aung (ORCID: https://orcid.org/0000-0003-4150-0426)
- David L. Rimm (ORCID: https://orcid.org/0000-0001-5820-4397)
- Sarah B. Goldberg (ORCID: https://orcid.org/0000-0002-0920-1381)
- Ioannis Athanasios Vathiotis (ORCID: https://orcid.org/0000-0002-1772-5986)
- Ryan D. Morrison (ORCID: https://orcid.org/0000-0003-4995-8001)
- Salisha Hill (ORCID: https://orcid.org/0000-0002-4145-969X)
- Nay Chan (ORCID: https://orcid.org/0009-0006-1633-6125)
- Konstantinos N. Syrigos (ORCID: https://orcid.org/0000-0002-3474-1363)
- Anna Wurtz
- Katerina Politi (ORCID: https://orcid.org/0000-0001-6064-4527)
- D.C. Liebler (ORCID: https://orcid.org/0000-0002-7873-3031)
- Nuriya Robinson (ORCID: https://orcid.org/0000-0003-1238-0381)
- Charles T. Robbins (ORCID: https://orcid.org/0000-0002-3130-7107)
- Katherine Bates (ORCID: https://orcid.org/0000-0001-8956-6331)
- Matthew Liu (ORCID: https://orcid.org/0000-0002-2229-5124)
- Mengni He (ORCID: https://orcid.org/0000-0003-4228-4462)
Institutions
- University of Iowa (US)
- National and Kapodistrian University of Athens (GR)
- Genmab (United States) (US)
- Yale University (US)
- Yale New Haven Health System (US)
- Nashville Oncology Associates (US)
- Sotiria General Hospital (GR)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3347
- Citations
- 3
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 4.56