Alpinoblonoids A and B, Two 16-<i>nor</i>-Labdane-Related Diterpenoids with a Tricyclic Carbon Skeleton from <i>Alpinia oblongifolia</i>
Alpinoblonoids A (<b>1</b>) and B (<b>2</b>), two 16-<i>nor</i>-labdane related diterpenoids featuring 2,6,6,10,11-pentamethyltricyclo[8.4.0.0<sup>2,7</sup>]tetradecane and 11-ethyl-2,6,6,10-tetramethyltricyclo[8.3.0.0<sup>2,7</sup>]tridecane skeletons, respectively, along with their biosynthetic precursor (<b>3</b>), were isolated from the rhizomes of <i>Alpinia oblongifolia</i>. Their structural elucidation was achieved by a variety of techniques, including spectroscopic and chemical methods, ECD calculations, as well as single-crystal X-ray diffraction. Compounds <b>1</b> and <b>2</b> exhibited antihepatic fibrosis activity by inhibiting the expressions of fibronectin, collagen I, and α-smooth muscle actin.
Authors
- B. Zhang
- De‐an Guo (ORCID: https://orcid.org/0000-0003-0223-9448)
- Yuwei Wu (ORCID: https://orcid.org/0000-0002-2033-8194)
- Wenxian Li
- Lu Gan (ORCID: https://orcid.org/0000-0003-4641-9336)
- Wei Li
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Drug Discovery Laboratory (Norway) (NO)
- Southern Medical University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1021/acs.orglett.5c00574
- Citations
- 6
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 9.34
Funders
- National Natural Science Foundation of China