Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions
This study highlights the biomarker-guided precision medicine strategy for drug repurposing. Pitavastatin and atorvastatin could be used to assist in the treatment of advanced CRC, particularly with CMS4 subtype CRC patients who also suffer from hyperglycemia. Pitavastatin, with an achievable dosage used for clinical interventions, is highly recommended for a novel CRC therapeutic strategy.
Authors
- Chi‐Ying F. Huang (ORCID: https://orcid.org/0000-0003-4898-4937)
- Tai‐Shan Cheng
- Yi‐Shiou Chiou (ORCID: https://orcid.org/0000-0002-0436-6603)
- Sin-Yu Chen
- Wei-Ming Cheng (ORCID: https://orcid.org/0000-0002-3967-6396)
- Thi‐Huong Nguyen (ORCID: https://orcid.org/0000-0002-9237-3482)
- Yu‐Feng Hu (ORCID: https://orcid.org/0000-0001-5715-2070)
- Ying Chang (ORCID: https://orcid.org/0000-0002-8375-6473)
- Tzu-Yi Huang
- Po-Chen Li
- Chih‐Wei Wu (ORCID: https://orcid.org/0000-0001-5242-6343)
- Hsiao‐Sheng Liu (ORCID: https://orcid.org/0000-0003-0576-7203)
- Ming‐Fen Lee (ORCID: https://orcid.org/0000-0003-2557-6527)
- Jinmei Lai (ORCID: https://orcid.org/0009-0003-5238-4720)
- Yu‐Tang Huang
- Peter Mu‐Hsin Chang (ORCID: https://orcid.org/0000-0003-1005-6545)
- Thu-Ha Tran (ORCID: https://orcid.org/0000-0002-2273-2793)
- Yi‐Ren Hong (ORCID: https://orcid.org/0000-0001-5470-6090)
- Minh Tran-Binh Nguyen
- Thu-Huyen Hoang
- Yu-Chieh Chu
- Yu-Teng Lin
Institutions
- Fu Jen Catholic University (TW)
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- China Medical University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Taipei Veterans General Hospital (TW)
- Genomics Research Center, Academia Sinica (TW)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- Far Eastern Memorial Hospital (TW)
- Taipei City Hospital (TW)
- Thai Nguyen University of Agriculture and Forestry (VN)
- Oxford University Clinical Research Unit (VN)
- Academia Sinica (TW)
- Stanford University (US)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s12935-025-03712-2
- Citations
- 9
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 8.43
Funders
- China Medical University, Taiwan
- Department of Health, Taipei City Government