Proteome remodeling upon disruption of virulence-associated CipC from <i>Cryptococcus neoformans</i>

The human fungal pathogen, <i>Cryptococcus neoformans</i>, produces an array of virulence factors that regulate the production of a polysaccharide capsule and melanin, thermotolerance, and the release of extracellular enzymes. Here, we applied quantitative proteomics to investigate the role of CipC, a known virulence-associated protein, in the fungus.