Quantum super-resolution microscopy by photon statistics and structured light

Reaching high-resolution imaging of delicate samples at a low-intensity level is a major challenge in microscopy. Here, we present and experimentally implement an advanced quantum super-resolution imaging technique based on photon statistics measurement. Our reconstruction algorithm adapts to any kind of non-Poissonian emitters, outperforming the corresponding classical SOFI method, in particular in low-light conditions. It offers sub-diffraction resolution improvement that scales with the j , where j is the highest-order central moments of the photocounts. More remarkably, we show that in combination with structured illumination, an improvement of j + j can be reached, providing a promising avenue for non-invasive super-resolution microscopy.

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Publication Details

Journal
Optica
Published
2025-03-06
DOI
https://doi.org/10.1364/optica.540264
Citations
8
Primary Topic
Advanced Fluorescence Microscopy Techniques
Type
article
Field-Weighted Citation Impact
13.07
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article

Quantum super-resolution microscopy by photon statistics and structured light

Marco Genovese, Fabio Picariello, Pauline Boucher, Ivo Pietro Degiovanni et al.
8 citations
Optica
Advanced Fluorescence Microscopy Techniques
13.07
article

Quantum super-resolution microscopy by photon statistics and structured light

Marco Genovese, Fabio Picariello, Pauline Boucher, Ivo Pietro Degiovanni, S. Ditalia Tchernij, Ivano Ruo Berchera, Elena Losero
article en
8 citations

Abstract

Reaching high-resolution imaging of delicate samples at a low-intensity level is a major challenge in microscopy. Here, we present and experimentally implement an advanced quantum super-resolution imaging technique based on photon statistics measurement. Our reconstruction algorithm adapts to any kind of non-Poissonian emitters, outperforming the corresponding classical SOFI method, in particular in low-light conditions. It offers sub-diffraction resolution improvement that scales with the j , where j is the highest-order central moments of the photocounts. More remarkably, we show that in combination with structured illumination, an improvement of j + j can be reached, providing a promising avenue for non-invasive super-resolution microscopy.

OpticaVol. 12(4)
Quanta Technology (United States) (US), Istituto Nazionale di Fisica Nucleare (IT), University of Turin (IT)
Openalex Percentile: Top 1%
Advanced Fluorescence Microscopy Techniques
13.07
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Quantum super-resolution microscopy by photon statistics and structured light — Marco Genovese, Fabio Picariello, et al. · Optica (2025) | TGRS Research Map | TGRS