Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes
IR adipocyte exosomes modify the TME, enhance EMT, and promote brain metastasis-likely via miRNA pathways-suggesting that metabolic diseases such as T2D foster a prometastatic TME, reducing survival and warranting close monitoring and potential metabolic interventions in patients with TNBC and T2D.
Authors
- Pablo Llévenes (ORCID: https://orcid.org/0000-0003-1925-7204)
- Rebecca Yu (ORCID: https://orcid.org/0000-0002-4137-7993)
- Yuhan Qiu (ORCID: https://orcid.org/0000-0003-3770-7977)
- Gerald V. Denis (ORCID: https://orcid.org/0000-0001-9886-0401)
- Naomi Y. Ko (ORCID: https://orcid.org/0000-0001-9689-9601)
- Stefano Monti (ORCID: https://orcid.org/0000-0002-9376-0660)
- Michael Seen (ORCID: https://orcid.org/0009-0008-7823-1526)
- Andrew Chen (ORCID: https://orcid.org/0000-0002-8508-0227)
Institutions
- Boston University (US)
- Boston Medical Center (US)
- University of Massachusetts Boston (US)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1158/1541-7786.mcr-24-0494
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.84