Precision Medicine in Cardiovascular Disease Prevention: Clinical Validation of Multi-Ancestry Polygenic Risk Scores in a U.S. Cohort
PRS-based risk stratification provides a reliable, ancestry-inclusive framework for personalized cardiovascular disease prevention, enabling better targeted interventions such as pharmacological therapy and lifestyle modifications. By incorporating genetic information from both coding and non-coding regions, PRSs refine risk prediction across diverse populations, advancing the integration of genomics into precision medicine for common diseases.
Authors
- Giordano Bottà (ORCID: https://orcid.org/0000-0002-7459-7570)
- Paolo Di Domenico
- Alessandro Bolli (ORCID: https://orcid.org/0000-0001-7259-5785)
- Małgorzata Ponikowska (ORCID: https://orcid.org/0000-0003-2788-8698)
- George Busby (ORCID: https://orcid.org/0000-0003-4148-6222)
- Emma Perez
Institutions
- Brigham and Women's Hospital (US)
- Gdańsk Medical University (PL)
Publication Details
- Journal
- Nutrients
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3390/nu17050926
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63