The local pulsatile parathyroid hormone delivery system induces the osteogenic differentiation of dental pulp mesenchymal stem cells to reconstruct mandibular defects
The rhythmic release of PTH from the pulsatile delivery system effectively induces the osteogenic differentiation of DPSCs. By leveraging the synergistic interaction between PTH and DPSCs, this approach facilitates the repair of extensive mandibular bone defects.
Authors
- Mianmian Duan
- Yuanyuan Jia (ORCID: https://orcid.org/0000-0002-8706-1281)
- Dongxiang Wang (ORCID: https://orcid.org/0000-0002-3189-0160)
- Zhenglong Tang (ORCID: https://orcid.org/0000-0001-6309-0486)
- Yan Yang (ORCID: https://orcid.org/0000-0002-1851-3096)
- Duchenhui Li
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s13287-025-04258-w
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Program of Guizhou Province