Large-scale CRISPRi screens link metabolic stress to glioblastoma chemoresistance
Our study reveals an unexpected link between metabolic stress and chemoresistance, demonstrating how metabolic adaptation can promote therapeutic resistance. These findings caution against single-agent metabolic targeting and suggest PGK1 as a potential biomarker for TMZ response in GBM.
Authors
- Tianhu Sun (ORCID: https://orcid.org/0000-0002-2513-1387)
- Ruilin Tian (ORCID: https://orcid.org/0000-0001-7680-6682)
- Wansong Zhang
- Yitong Fang (ORCID: https://orcid.org/0000-0001-7255-0958)
- Jian Chen (ORCID: https://orcid.org/0000-0002-0438-7631)
- Xing Li
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Southern University of Science and Technology (CN)
- Chinese Institute for Brain Research (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s12967-025-06261-4
- Citations
- 6
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.75
Funders
- National Natural Science Foundation of China
- Shenzhen Fundamental Research Program
- Basic and Applied Basic Research Foundation of Guangdong Province