Tailored Surgery for Medullary Thyroid Cancer (MTC) Based on Pretherapeutic Basal Calcitonin and Intraoperative Diagnosis of Desmoplastic Stroma Reaction: A Proposal for a New Surgical Concept
The analysis facilitates the recommendation to individualize the extent of LND combining pretherapeutic bCt and the presence of DSR. Independent of bCt levels (risk groups), LND can be avoided following thyroidectomy in patients with DSR-negative tumors. Patients with DSR-positive tumors should undergo thyroidectomy and bilateral CND. In addition, in "high risk" patients, unilateral LND is recommended in those with bCt < 350 pg/mL. Bilateral LND should be discussed in patients with M0 status and bCt > 350 pg/mL.
Authors
- Bruno Niederle (ORCID: https://orcid.org/0000-0001-8107-4068)
- Christian Scheuba (ORCID: https://orcid.org/0000-0001-7632-2506)
- Philipp Riss (ORCID: https://orcid.org/0000-0003-1472-6606)
- Martin B. Niederle (ORCID: https://orcid.org/0000-0003-0450-6132)
- Teresa Binter (ORCID: https://orcid.org/0000-0002-9930-2767)
Institutions
- Vienna General Hospital (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1245/s10434-025-16958-x
- Citations
- 7
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.06
Funders
- Medizinische Universität Wien