Study on HIF-PHI combined with iron supplement in treatment of renal anemia in rats
HIF-PHI combined with iron supplement (Roxadustat combined with PIC) has an improved effect on the treatment of renal anemia, and early administration of sufficient iron enables the Hb to rise rapidly. Early administration of adequate dose of PIC is necessary for renal anemia. HIF-PHI can improve iron metabolism, alleviate the microinflammatory state, alleviate renal fibrosis and plays a beneficial role in the treatment of renal fibrosis in CKD rats.
Authors
- Zhaoli Gao (ORCID: https://orcid.org/0000-0003-3114-2207)
- Zhao Hu (ORCID: https://orcid.org/0000-0002-0205-2707)
- Shuen Li
- Hailin Lv (ORCID: https://orcid.org/0000-0001-6667-5463)
- Yanxia Gao (ORCID: https://orcid.org/0000-0001-5054-6624)
- Haoran Xue (ORCID: https://orcid.org/0000-0001-5003-5816)
- Qi Wang (ORCID: https://orcid.org/0000-0002-1728-8763)
- Peng Lu (ORCID: https://orcid.org/0000-0002-9427-0313)
- Xiaotian Ma (ORCID: https://orcid.org/0009-0005-9462-2170)
- Qiang Wang (ORCID: https://orcid.org/0000-0003-4392-0889)
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s12882-025-04045-y
- Citations
- 2
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.54