The <i>TCF4</i> Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy
This study demonstrates a crucial role for TCF4 in FECD pathogenesis, particularly in ECM regulation and protein aggregation-induced cell death.
Authors
- Vivek Ghose
- Theofilos Tourtas (ORCID: https://orcid.org/0000-0002-3465-9837)
- Naoki Okumura (ORCID: https://orcid.org/0000-0003-2275-5263)
- Ursula Schlötzer‐Schrehardt (ORCID: https://orcid.org/0000-0001-8423-7395)
- Masakazu Sato (ORCID: https://orcid.org/0000-0002-5703-6288)
- Amit Chatterjee (ORCID: https://orcid.org/0000-0001-6233-5357)
- Prema Padmanabhan (ORCID: https://orcid.org/0000-0001-7248-9907)
- Narayanan Janakiraman (ORCID: https://orcid.org/0000-0003-0866-9828)
- Gajanan Sathe (ORCID: https://orcid.org/0000-0002-6239-5365)
- Derek J. Blake (ORCID: https://orcid.org/0000-0002-5005-4731)
- Sailaja Elchuri (ORCID: https://orcid.org/0000-0002-9780-2717)
- Go Nishiuchi
- Noriko Koizumi (ORCID: https://orcid.org/0000-0002-6940-1334)
- Ayumi Tokunaga
- Makiko Nakahara
- Taichi Yuasa
- Friedrich E. Kruse
- Tatsuya Nakagawa
- Tetsuro Honda
Institutions
- Sankara Nethralaya (IN)
- Doshisha University (JP)
- Manipal Academy of Higher Education (IN)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Institute of Bioinformatics (IN)
- Cardiff University (GB)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1167/iovs.66.3.16
- Citations
- 5
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.80
Funders
- Japan Society for the Promotion of Science
- Science and Engineering Research Board