The Complex Interactions Between Micronutrients, Iron Overload, and Health Outcomes in Iraqi Thalassemia Patients

Patients with thalassemia face a heightened risk of mineral deficiency due to elevated oxidative stress and the effects of iron chelation therapies. The Objective of the Study:- investigate the impact of iron overload on the variations in micronutrient levels in patients diagnosed with significant β-thalassemia. This case-control study is from August 2024 to December 2024. The study involved 100 participants, 50 of whom had significant β-thalassemia (25 males and 25 females) and 50 healthy controls (25 males and 25 females), aged 19 to 25. The ferritin, iron, and micronutrients were employed to conduct assays using the COBAS diagnostic test system. The results were calculated as the mean and standard error, presented in the format mean±standard error. A one-way analysis of variance (ANOVA) was employed to assess the data, with statistical significance determined at p<0.05 to find noteworthy differences. The results illustrated increased in zinc, magnesium, and manganese inpatient group when compared with control group. Unlike that copper, and calcium decrease significantly in patient group when compared with control group [1].