Sauchinone preserves cardiac function in doxorubicin-induced cardiomyopathy by inhibiting the NLRP3 inflammasome
The key novel finding of the present study is that the use of sauchinone, a diastereomeric lignan isolated from Saururus chinensis, effectively limits the progression of DIC. Specifically, sauchinone not only alleviates Dox-induced chronic cardiac injury but also significantly delays the progression of acute DIC. Mechanistically, inactivation of the NLRP3 inflammasome and NRF2-mediated antioxidant pathways have been identified as two critical signaling pathways regulated by sauchinone, which plays a vital role in blocking the progression of DIC. Sauchinone holds promise as a potential therapeutic approach for DIC or dilated cardiomyopathy.
Authors
- Miao He (ORCID: https://orcid.org/0000-0003-2385-794X)
- Yueyue Wu (ORCID: https://orcid.org/0000-0002-6237-3430)
- Yining Zhao (ORCID: https://orcid.org/0000-0002-3156-0858)
- Xinyu Heng
- Nian X. Sun (ORCID: https://orcid.org/0000-0002-3120-0094)
- Yicong Shen (ORCID: https://orcid.org/0000-0002-8526-2338)
- Yankui Liu
- Wei Zhang
- Xiuxia Qu
- Ke Zhang (ORCID: https://orcid.org/0000-0003-3081-7751)
- Lin Pu
- Tao Xu (ORCID: https://orcid.org/0000-0001-5868-4079)
- Chao Ye (ORCID: https://orcid.org/0000-0002-9897-0085)
- Wei Xin
- Dongliang Han (ORCID: https://orcid.org/0000-0002-4098-0379)
- Hai Yang
Institutions
- Jiangnan University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1016/j.phymed.2025.156624
- Citations
- 9
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 12.49