Bleeding symptoms in persons with rare bleeding disorders and a heterozygous genotype: data from the Rare Bleeding Disorders in the Netherlands study
In our population with rare bleeding disorders, the majority of persons possessing a heterozygous genotype exhibited spontaneous bleeding symptoms. Especially in intermediate-high risk procedures, a proactive approach to periprocedural hemostatic treatment in persons with a heterozygous genotype seems beneficial.
Authors
- Nicole M. A. Blijlevens
- Paul L. den Exter (ORCID: https://orcid.org/0000-0002-1543-5731)
- Joline L. Saes (ORCID: https://orcid.org/0000-0003-3219-4981)
- Marjan M. Weiss (ORCID: https://orcid.org/0000-0002-0936-1406)
- Marjon H. Cnossen (ORCID: https://orcid.org/0000-0003-1557-2995)
- Saskia E.M. Schols (ORCID: https://orcid.org/0000-0003-2423-2829)
- Laurens Nieuwenhuizen (ORCID: https://orcid.org/0000-0002-0494-9374)
- Nick van Es (ORCID: https://orcid.org/0000-0001-5256-6346)
- Karina Meijer (ORCID: https://orcid.org/0000-0001-9447-0465)
- Ilmar C. Kruis (ORCID: https://orcid.org/0000-0003-4118-4670)
- Dominique P.M.S.M. Maas (ORCID: https://orcid.org/0000-0003-1169-4354)
- Waander L. van Heerde (ORCID: https://orcid.org/0000-0001-7101-8775)
- Sara M. Willems (ORCID: https://orcid.org/0000-0002-6803-3007)
- Roger Schutgens
- Annet Simons (ORCID: https://orcid.org/0000-0001-5087-4759)
- Sanna R. Rijpma
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Dutch Cancer Society (NL)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Amsterdam Neuroscience (NL)
- Máxima Medisch Centrum (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Amsterdam University Medical Centers (NL)
- Netherlands Haemophilia Society
- Amsterdam University of Applied Sciences (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1016/j.jtha.2025.02.030
- Citations
- 2
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.25