Methodology Concerns Regarding Claims Data Studies in Transgender Health

To the Editor The recent study by Manfredi et al1 found a lower prevalence of prostate cancer (PC) in transgender women undergoing gender-affirming hormone therapy (GAHT), but a correlation between GAHT and more aggressive PC. We have concerns regarding the analyses and conclusions.

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Publication Details

Journal
JAMA Oncology
Published
2025-03-06
DOI
https://doi.org/10.1001/jamaoncol.2025.0020
Citations
2
Primary Topic
LGBTQ Health, Identity, and Policy
Type
article
Field-Weighted Citation Impact
4.88
Controls
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article

Methodology Concerns Regarding Claims Data Studies in Transgender Health

Alberto Giovanni Leone, Don S. Dizon, Ole‐Petter R. Hamnvik
2 citations
JAMA Oncology
LGBTQ Health, Identity, and Policy
4.88
article

Methodology Concerns Regarding Claims Data Studies in Transgender Health

Alberto Giovanni Leone, Don S. Dizon, Ole‐Petter R. Hamnvik
article en
2 citations

Abstract

To the Editor The recent study by Manfredi et al1 found a lower prevalence of prostate cancer (PC) in transgender women undergoing gender-affirming hormone therapy (GAHT), but a correlation between GAHT and more aggressive PC. We have concerns regarding the analyses and conclusions.

JAMA OncologyVol. 11(5)
Brigham and Women's Hospital (US), Harvard University (US), Providence College (US), Brown University (US), Chelsea and Westminster Hospital (GB), Lifespan (US), Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
Gender equality
Openalex Percentile: Top 7%
LGBTQ Health, Identity, and Policy
4.88
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Methodology Concerns Regarding Claims Data Studies in Transgender Health — Alberto Giovanni Leone, Don S. Dizon, et al. · JAMA Oncology (2025) | TGRS Research Map | TGRS