Glucagon-like peptide-1 receptor signaling activation in alveolar type II cells enhances lung development in neonatal rats exposed to hyperoxia
GLP-1R is primarily expressed in ATII cells of neonatal rats and can promote lung development during the early postnatal period. The GLP-1R signaling pathway modulates mitochondrial fission and glucose metabolism in ATII cells under hyperoxia. Hyperoxia can inhibit the activation of GLP-1R by inhibiting m6A methylation during BPD pathogenesis.
Authors
- Haiyang Yu (ORCID: https://orcid.org/0000-0003-1314-6706)
- Dingning Zhang (ORCID: https://orcid.org/0000-0003-4616-1232)
- Danni Li (ORCID: https://orcid.org/0000-0002-1882-7394)
- Jianhua Fu
- Dan Zhang (ORCID: https://orcid.org/0000-0001-7475-0750)
- T. Sun
Institutions
- China Medical University (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1016/j.redox.2025.103586
- Citations
- 3
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56