Influence of Repeated Exposure to Neonatal Isoflurane on Sleep Architecture and Neuronal Delta and Theta Oscillations in Adolescent Rats
Exposing neonatal rats to isoflurane repeatedly causes significant neurotoxicity, and alters delta and theta thalamocortical oscillations, as well as sleep architecture in adolescence. This contrasts with a single continuous exposure to isoflurane, in which we previously reported no significant effects on sleep-wake architecture and only minimal effect on beta oscillations despite similar acute neurotoxicity.
Authors
- Arthur J. Armijo (ORCID: https://orcid.org/0000-0002-0773-4854)
- Slobodan M. Todorovic
- Brier Fine-Raquet
- Francesca M. Manzella (ORCID: https://orcid.org/0000-0003-1296-2015)
- Nemanja Useinovic (ORCID: https://orcid.org/0000-0003-2788-7441)
- Vesna Jevtović‐Todorović (ORCID: https://orcid.org/0000-0001-8688-9768)
Institutions
- Rocky Vista University (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1213/ane.0000000000007462
- Citations
- 1
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 1.32