Three-year safety and effectiveness of tofacitinib in patients with rheumatoid arthritis in Japan: Final analysis of an all-case postmarketing surveillance study
Serious infection rates were higher, and malignancy rates were numerically higher with tofacitinib vs control. Results should be interpreted cautiously due to imbalanced groups and unmeasured confounders.
Authors
- Nobunori Takahashi (ORCID: https://orcid.org/0000-0001-6937-3567)
- Michiaki Takagi (ORCID: https://orcid.org/0000-0002-3052-787X)
- Nami Okamoto (ORCID: https://orcid.org/0000-0002-9085-5250)
- Masayoshi Harigai (ORCID: https://orcid.org/0000-0002-6418-2603)
- Yoshiya Tanaka (ORCID: https://orcid.org/0000-0002-0807-7139)
- Tsuneyo Mimori (ORCID: https://orcid.org/0000-0003-0016-2053)
- Yutaka Endo (ORCID: https://orcid.org/0000-0001-7187-0124)
- Toshitaka Hirano
- Sakae Tanaka (ORCID: https://orcid.org/0000-0001-9210-9414)
- Naoto Tamura (ORCID: https://orcid.org/0000-0003-1729-2954)
- Hiroaki Matsuno (ORCID: https://orcid.org/0000-0002-2195-5717)
- Naonobu Sugiyama (ORCID: https://orcid.org/0000-0002-5008-0665)
- Syuji Takei (ORCID: https://orcid.org/0000-0003-3905-0737)
- Masataka Kuwana (ORCID: https://orcid.org/0000-0001-8352-6136)
- Yoshinari Takasaki (ORCID: https://orcid.org/0000-0001-7627-8445)
- Tatsuya Atsumi (ORCID: https://orcid.org/0000-0001-5657-962X)
- Shigeki Momohara (ORCID: https://orcid.org/0000-0002-5954-0664)
- Tsutomu Takeuchi (ORCID: https://orcid.org/0000-0003-1111-8218)
- Takao Fujii (ORCID: https://orcid.org/0000-0002-1789-1984)
- Masato Hoshi (ORCID: https://orcid.org/0000-0003-2874-1807)
- Kazuhiko Yamamoto (ORCID: https://orcid.org/0000-0002-9931-889X)
- Atsuo Nakajima
- Ayako Nakajima (ORCID: https://orcid.org/0000-0002-6789-1739)
- Miki Tanigawa
Institutions
- Kagoshima University (JP)
- Yamagata University (JP)
- Aichi Medical University (JP)
- University of Occupational and Environmental Health Japan (JP)
- Wakayama Medical University (JP)
- Keio University (JP)
- Hokkaido University (JP)
- Kyoto University (JP)
- Juntendo University (JP)
- Osaka Rosai Hospital (JP)
- Japanese Society for Dialysis Therapy (JP)
- Institute for Rheumatic Diseases (Japan) (JP)
- Mie University Hospital (JP)
- Tokyo Women's Medical University (JP)
- Hokkaido University Hospital (JP)
- Pfizer (Japan) (JP)
- Takeda (France) (FR)
- Takeda (Japan) (JP)
- The University of Tokyo (JP)
- Nippon Medical School (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- Modern Rheumatology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1093/mr/roaf017
- Citations
- 3
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 5.00