The role of molecular genetic markers in the combination of arterial hypertension and vibration disease

Introduction. When vibration disease (VS) and arterial hypertension (AH) are combined, disturbances in cellular-molecular interactions associated with increased concentrations of pro-inflammatory cytokines, oxidative stress, endothelial dysfunction, hormonal and metabolic disorders naturally lead to a transformation in the architecture of blood vessels, in addition to the risk of development and progression microcirculatory disorders with a combination of vibration disease and arterial hypertension is determined by gene polymorphisms. Target. Based on the study of clinical-functional, sanitary-hygienic and molecular-genetic indicators, develop additional diagnostic criteria for nutritional-metabolic disorders in vibration disease and arterial hypertension. Materials and methods. A single-center, open, non-randomized, cross-sectional study was conducted. The participants were divided into groups: 1st - patients diagnosed with stage I vibration disease. (n = 104); 2nd - patients diagnosed with hypertension stages I-II (n = 107); Group 3 - patients with similar parameters of the vibration disease and arterial hypertension groups (n = 101); 4th (control) - conditionally healthy individuals working at the same enterprise without contact with vibration and not having a diagnosis of hypertension (n = 119). Results. In the group of combinations of vibration disease and arterial hypertension, the body mass index corresponds to obesity grades 2 and 3. in 27.1%; 15.8%; whereas in the groups of only vibration disease and only arterial hypertension, obesity of the 1st degree predominates; a decrease in active cell mass and phase angle was recorded in the group with a combination of vibration disease and arterial hypertension compared to the control group by 1.4 and 1.3 times, respectively (p<0.001). In the group of vibration disease combined with arterial hypertension, the greatest increase of all study groups was found in the concentrations of oxidative stress indicators, MMP-1, MMP-9, neutrophil elastase, pentraxin 3, a decrease in parameters of the total antioxidant status of serum, the Cu/ZnSOD indicator, and an increase in pro-inflammatory cytokines IL -1β. In the same group, the frequency of occurrence of the T/T rs4880 genotype of the superoxide dismutase gene MnSOD was characteristic of oxidative stress, while carriage of the G/C rs20417 genotype of the COX2 cyclooxygenase gene did not affect the course of vibration disease combined with arterial hypertension. Conclusions. The combination of vibration disease and arterial hypertension occurs under conditions of nutritional and metabolic changes in conjunction with systemic inflammation, endothelial dysfunction, oxidative stress and an increased frequency of occurrence of the T/T nucleotide sequence variant of the Ala16Val locus (rs4880) of the MnSOD gene. The results of our own research based on the correlation and regression analysis made it possible to develop additional diagnostic criteria for nutritional and metabolic disorders in vibration disease combined with arterial hypertension.