Unraveling enhanced liver regeneration in ALPPS: Integrating multi-omics profiling and in vivo CRISPR in mouse models
ALPPS could successfully promote liver regeneration by activating hepatocytes into a proliferative state. Moreover, a Plk1-related 30-gene signature was identified to predict the cell state of hepatocytes. miR-30a-3p might be able to regulate the expression of Plk1, contributing to the liver regeneration of ALPPS.
Authors
- Fei Zhang (ORCID: https://orcid.org/0000-0001-9776-3861)
- John Yin (ORCID: https://orcid.org/0000-0001-6146-0594)
- Yifei Zhang (ORCID: https://orcid.org/0000-0002-6865-5586)
- Yang Yihan (ORCID: https://orcid.org/0000-0001-6047-2219)
- Junjun Wu (ORCID: https://orcid.org/0000-0002-7387-971X)
- Yuan Du (ORCID: https://orcid.org/0000-0003-2864-9947)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1097/hc9.0000000000000630
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00