Second harmonic generation microscopy reveals the spatial orientation of glutamine-potentiated liver regeneration after hepatectomy
Gln promotes liver regeneration through cellular proliferation and metabolic reprogramming after hepatectomy. Using structure-based imaging, we found that Gln potentiated hepatic steatosis and ECM collagen deposition predominantly in the portal tract area. These results highlighted the spatial orientation and mechanistic implications of Gln in liver regeneration.
Authors
- Hung‐Wen Tsai (ORCID: https://orcid.org/0000-0001-9223-2535)
- Chih‐Chieh Yen (ORCID: https://orcid.org/0000-0002-3109-2783)
- I-Ting Liu (ORCID: https://orcid.org/0000-0002-6454-8855)
- Yan‐Shen Shan (ORCID: https://orcid.org/0000-0002-2457-5189)
- Chia‐Jui Yen (ORCID: https://orcid.org/0000-0001-8744-6248)
- Wen-Lung Wang
- Chia-Sheng Yen (ORCID: https://orcid.org/0000-0002-1538-2959)
- Matthew M. Yeh (ORCID: https://orcid.org/0000-0002-3004-8799)
- Tse-Ming Hong (ORCID: https://orcid.org/0000-0002-9333-8451)
Institutions
- University of Washington (US)
- Kaohsiung Veterans General Hospital (TW)
- National Cheng Kung University Hospital (TW)
- Meiho University (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1097/hc9.0000000000000640
- Citations
- 2
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.64