Primary squamous cell carcinoma complicated with invasive ductal carcinoma of breast

Primary Squamous Cell Carcinoma (SCC) of the breast, a rare subtype of metaplastic carcinoma, is estimated to occur in less than 0.1% of breast cancer cases. In clinical practice, the coexistence of primary SCC with Invasive Ductal Carcinoma (IDC) is exceptionally rare, presenting unique challenges in diagnosis and management. We report a patient with primary SCC complicated with IDC of the breast. This patient underwent operation, adjuvant chemotherapy and endocrine therapy according to the Breast Cancer Guidelines. Primary SCC of the breast is recognized for its highly aggressive nature and resistance to treatment, often associated with a poor prognosis. Currently, there are no specific guidelines dedicated to the management of primary SCC of the breast. When primary SCC coexists with IDC of the breast, the prognosis becomes even more uncertain due to the complex interplay between these two distinct pathological entities. In this case, we have adopted a treatment strategy targeting the IDC component, following established guidelines for breast cancer management. We anticipate that this approach will contribute to a favorable prognosis for the patient.