Evaluation of FXR Activity in Pollutants Identified in Sewage Sludge and Subsequent <i>in Vitro</i> and <i>in Vivo</i> Characterization of Metabolic Effects of Triphenyl Phosphate
Nineteen FXR-antagonistic pollutants were identified in sewage sludge. FXR inhibition by the strongest antagonist TPHP may have a role in promoting MASLD development in mice by inducing a positive feedback loop between the FXR and BAs. https://doi.org/10.1289/EHP15435.
Authors
- Yixuan Huang (ORCID: https://orcid.org/0000-0003-1679-8435)
- Hailin Shang (ORCID: https://orcid.org/0009-0006-1068-7143)
- Enrui Li
- Yi Yang
- Hong Chang (ORCID: https://orcid.org/0000-0002-7586-9769)
- Ling Jiao
- Hongyang Cui (ORCID: https://orcid.org/0000-0002-2809-7110)
- Yi Wan (ORCID: https://orcid.org/0000-0003-1312-6254)
Institutions
- Peking University (CN)
- Beijing Forestry University (CN)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1289/ehp15435
- Citations
- 1
- Primary Topic
- Dye analysis and toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.75