A Size-Adaptive Nanomicrobicide for Synergistic Photothermal and Gaseous Dismantling of Multidrug-Resistant Biofilms
Biofilms significantly impede the efficacy of conventional antimicrobial agents, particularly in multidrug-resistant (MDR) infections. In this work, we developed a size-adaptive, bismuth-based nanomicrobicide encapsulated with neutrophil membranes (Bi<sub>2</sub>S<sub>3</sub>/SNP@CM), designed to selectively generate nitric oxide (NO) within acidic biofilms under near-infrared (NIR) irradiation. The nanomicrobicide's adaptive size ensures deeper biofilm penetration and accumulation, while the neutrophil membrane coating enhances biocompatibility and targeting at infection sites. Upon NIR irradiation, localized heating and NO release synergistically eradicate MDR biofilms. Furthermore, the interactions between the nanomicrobicide and glutathione, as well as the reactions between NO and ROS, disrupt the intracellular redox balance, further amplifying the antibacterial efficacy. This innovative design affords a promising nanomicrobicide for effectively treating MDR biofilm infections.
Authors
- Bo Li (ORCID: https://orcid.org/0000-0001-9766-7925)
- Yizhi Dai
- Fene Gao
- Jinglong Tang (ORCID: https://orcid.org/0000-0001-9981-7966)
- Sibo Zhao
- Yuan Zhang (ORCID: https://orcid.org/0000-0002-1624-3715)
- Jing Liu (ORCID: https://orcid.org/0000-0002-8740-4600)
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0001-6078-9611)
- Hui Wang (ORCID: https://orcid.org/0000-0003-4321-9160)
- Wanjun Zhang (ORCID: https://orcid.org/0009-0000-0283-2407)
- Weiyu Zhang
- Shipeng Zhang (ORCID: https://orcid.org/0000-0003-2433-549X)
- Jiahui Mao (ORCID: https://orcid.org/0009-0005-6402-2641)
- Xin Li (ORCID: https://orcid.org/0000-0001-6020-9170)
- Aroofa Zargul
Institutions
- Qingdao University (CN)
- Ministry of Education of the People's Republic of China (CN)
- Northwest University (CN)
- National Clinical Research (US)
- National Center for Nanoscience and Technology (CN)
- University of Chinese Academy of Sciences (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Nano Letters
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1021/acs.nanolett.4c06221
- Citations
- 12
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 8.09
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Beijing Nova Program
- National Key Research and Development Program of China