Chemical constituents from <i>Ficus vogeliana</i> Miq (Moraceae)
The chemical investigations of the methanolic root, stem bark, leaf, and fruit extracts of <i>Ficus vogeliana</i> Miq (Moraceae) led to the isolation of nineteen different compounds including one new triglyceride derivative named vogelianor (<b>1</b>), two compounds (<b>2</b> and <b>4</b>) obtained for the first time from a natural source, as well as sixteen known compounds (<b>3, 5 </b>-<b> 19</b>). The structures of all the isolates were established by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. Compound <b>7</b> showed moderate activity against <i>E. coli</i> with a MIC value of 31.25 µg/mL, whilst compound <b>13</b> exhibited moderate activity against <i>S. typhimurium</i> with MIC value of 31.25 µg/mL. The leaf, root, and stem bark extracts displayed significant potency against <i>E. coli</i> with MIC values of 62.5 μg/mL, 31.25 µg/mL, and 62.5 μg/mL, respectively. Finally, the chemophenetic significance of the isolated compounds is discussed.
Authors
- Gervais Mouthé Happi (ORCID: https://orcid.org/0000-0001-9659-6125)
- Willifred Dongmo Tékapi Tsopgni (ORCID: https://orcid.org/0000-0002-1644-8171)
- Mohamed Foundikou Nsangou (ORCID: https://orcid.org/0000-0001-7638-9348)
- Emmanuel Ngeufa Happi (ORCID: https://orcid.org/0000-0002-2276-3709)
- Alain Tadjong Tcho (ORCID: https://orcid.org/0000-0001-6625-807X)
- Vanini Samiyatou Michiren Mandou (ORCID: https://orcid.org/0000-0001-5891-070X)
- Klev Gaïtan Sikam (ORCID: https://orcid.org/0000-0002-1582-6994)
- Marie Pascaline Deussom
- Eitel Mouellé Ngoh Missé
- Mohamar J. R. Njindi Kouotou
Institutions
- University of Buea (CM)
- University of Douala (CM)
- University of Bamenda (CM)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1080/14786419.2025.2471840
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00