Chemical constituents from <i>Ficus vogeliana</i> Miq (Moraceae)

The chemical investigations of the methanolic root, stem bark, leaf, and fruit extracts of <i>Ficus vogeliana</i> Miq (Moraceae) led to the isolation of nineteen different compounds including one new triglyceride derivative named vogelianor (<b>1</b>), two compounds (<b>2</b> and <b>4</b>) obtained for the first time from a natural source, as well as sixteen known compounds (<b>3, 5 </b>-<b> 19</b>). The structures of all the isolates were established by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. Compound <b>7</b> showed moderate activity against <i>E. coli</i> with a MIC value of 31.25 µg/mL, whilst compound <b>13</b> exhibited moderate activity against <i>S. typhimurium</i> with MIC value of 31.25 µg/mL. The leaf, root, and stem bark extracts displayed significant potency against <i>E. coli</i> with MIC values of 62.5 μg/mL, 31.25 µg/mL, and 62.5 μg/mL, respectively. Finally, the chemophenetic significance of the isolated compounds is discussed.

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Publication Details

Journal
Natural Product Research
Published
2025-03-06
DOI
https://doi.org/10.1080/14786419.2025.2471840
Primary Topic
Phytochemistry and Biological Activities
Type
article
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article

Chemical constituents from Ficus vogeliana Miq (Moraceae)

Gervais Mouthé Happi, Willifred Dongmo Tékapi Tsopgni, Mohamed Foundikou Nsangou, Emmanuel Ngeufa Happi et al.
Natural Product Research
Phytochemistry and Biological Activities
article

Chemical constituents from Ficus vogeliana Miq (Moraceae)

Gervais Mouthé Happi, Willifred Dongmo Tékapi Tsopgni, Mohamed Foundikou Nsangou, Emmanuel Ngeufa Happi, Alain Tadjong Tcho, Vanini Samiyatou Michiren Mandou, Klev Gaïtan Sikam, Marie Pascaline Deussom, Eitel Mouellé Ngoh Missé, Mohamar J. R. Njindi Kouotou
article en

Abstract

The chemical investigations of the methanolic root, stem bark, leaf, and fruit extracts of <i>Ficus vogeliana</i> Miq (Moraceae) led to the isolation of nineteen different compounds including one new triglyceride derivative named vogelianor (<b>1</b>), two compounds (<b>2</b> and <b>4</b>) obtained for the first time from a natural source, as well as sixteen known compounds (<b>3, 5 </b>-<b> 19</b>). The structures of all the isolates were established by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. Compound <b>7</b> showed moderate activity against <i>E. coli</i> with a MIC value of 31.25 µg/mL, whilst compound <b>13</b> exhibited moderate activity against <i>S. typhimurium</i> with MIC value of 31.25 µg/mL. The leaf, root, and stem bark extracts displayed significant potency against <i>E. coli</i> with MIC values of 62.5 μg/mL, 31.25 µg/mL, and 62.5 μg/mL, respectively. Finally, the chemophenetic significance of the isolated compounds is discussed.

Natural Product Research
University of Buea (CM), University of Douala (CM), University of Bamenda (CM)
Zero hunger
Openalex Percentile: Top 97%
Phytochemistry and Biological Activities
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