Effect of Hyperbaric Bupivacaine Injection Speed of 20 vs 40 Seconds Along with Preload Colloid on Hemodynamics in Caesarean Women

Objective: To compare 20 seconds vs 40 seconds hyperbaric bupivacaine speed along with preload colloid in the prevention of hemodynamics like hypotension in caesarean women. Methodology: This randomized controlled trial study was conducted in Anesthesia Department, Federal General Hospital, Islamabad from November to May 2023. Total 100 women undergoing cesarean section were systematically randomly equally allocated to hyperbaric bupivacaine injection in 20 seconds speed (n=50) or 40 seconds speed (n=50) along with preload colloid. Study outcome was hemodynamics (hypotension, heart rate and side effects) between two groups. The study outcome was measured in terms of patient hemodynamics considered as incidence of hypotension. The incidence of hypotension and nausea were compared using chi-square test. A probability level of 0.05 was considered statistically significant. . Data was analyzed in SPSS version 25.0. Results: Patients demographics and gestational history was found comparable in the two groups. The average systolic and diastolic BP varied from 4 to 15 minutes after anesthesia induction. The incidence of hypotension was significantly high in the 40 seconds preload colloid group 27 (54.0%) compared to 12 (24.0%) in the 20 seconds group (p-value, <0.001). Rate of nausea was found similar in two study groups. Conclusion: Incidence of hypotension was significantly high in 40 seconds group compared to 20 seconds injection speed of bupivacaine in this study.