Methionine-mediated trade-off between plant growth and salt tolerance

Salt stress is an important environmental factor that limits plant growth and development. A better understanding of the molecular mechanisms underlying plant salt tolerance will help improve plant performance and crop production under saline conditions. Here, we found that the amino acid methionine significantly improves plant salt tolerance. The salinity-induced activation of key genes governing methionine biosynthesis, namely Hcy-S-methyltransferases (HMTs) and methionine synthases (MSs), is controlled by the concerted interplay of abscisic acid (ABA) and reactive oxygen species signaling. This orchestrated gene activation subsequently leads to methionine accumulation, activating ABA signaling and improving plant salt tolerance. Beyond its role in modulating ABA signaling, methionine affects root growth dynamics by suppressing auxin and cytokinin signaling and impeding cell cycle progression. These multiple effects on growth-related signaling pathways lead to an effective redistribution of energy resources to improve the plant's ability to combat salt-induced stress. Our findings underscore methionine's pivotal involvement in enhancing plant adaptation to salinity stress by establishing a delicate balance between growth and salt tolerance. This mechanistic understanding sheds light on a compelling way to increase crop yields in saline soils and provides a strategic framework for sustainable agricultural practices in challenging environments.