Chemical Targeting of Prolyl-tRNA Synthetase Stalls Ovarian Development and Kills Malaria Vectors
Our data suggest the potential for repositioning HFG and pyrrolidine-based adenosine triphosphate mimetic (L95) as larvicides. Targeting the vector-encoded aminoacyl-tRNA synthetases provides a new focus for developing effective agents that can control multiple mosquito-borne infectious diseases such as malaria and dengue.
Authors
- Ritu Goswami
- M. Yogavel (ORCID: https://orcid.org/0000-0002-2119-062X)
- Jyoti Chhibber Goel
- Amit Sharma (ORCID: https://orcid.org/0000-0002-3305-0034)
- Swati Gupta (ORCID: https://orcid.org/0000-0003-0590-4060)
- B M Shrinivasa
Institutions
- Centro de Ingeniería Genética y Biotecnología (CU)
- International Centre for Genetic Engineering and Biotechnology (IN)
- National Institute of Malaria Research (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1093/infdis/jiaf095
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00