Pharmacokinetics, side effects, dosage forms, drug interactions of curcu-mine
This review presents current data on the pharmacokinetics, side effects, dosage forms and interactions of curcumin. Curcumin, the major bioactive component of turmeric, has low bioavailability due to its low water solubility, rapid metabolism in the liver and rapid excretion from the body. The main pathways of curcumin metabolism are described, including its reduction and subsequent conjugation with glucuronic acid and sulphates. Side effects of curcumin such as hyperoxaluria, iron deficiency anaemia, hepatotoxicity, arrhythmias, allergic reactions and potential carcinogenic properties are discussed. Various dosage forms of curcumin developed to enhance its bioavailability are discussed, including liposomes, nanoparticles, hydrogels and phytosomes. Particular attention is given to the drug interactions of curcumin with chemotherapeutic agents such as 5-fluorouracil, vincristine, gemcitabine, adriamycin and cisplatin, as well as with hypolipidaemic agents, antiaggregants and anticoagulants. These data highlight the need for further studies to optimise the therapeutic use of curcumin and minimise its side effects.
Authors
- Evgeny Pokushalov (ORCID: https://orcid.org/0000-0002-9494-4234)
- Михаил В. Хвостов (ORCID: https://orcid.org/0000-0002-5906-4223)
- M. F. Novikova (ORCID: https://orcid.org/0009-0008-7479-8277)
- E. V. Shrayner (ORCID: https://orcid.org/0000-0003-3606-4068)
- K. M. Nikolaychuk
- Т. Г. Толстикова (ORCID: https://orcid.org/0000-0002-3750-2958)
- А. И. Хавкин (ORCID: https://orcid.org/0000-0001-7308-7280)
- D. A. Lukichev
- A. S. Veremenko (ORCID: https://orcid.org/0009-0002-9228-2350)
- I. D. Levchenko (ORCID: https://orcid.org/0009-0002-7317-6077)
- E. E. Vergunova (ORCID: https://orcid.org/0009-0003-0793-4236)
- A. S. Tumas (ORCID: https://orcid.org/0009-0004-1138-6049)
- P. Ya. Platonova (ORCID: https://orcid.org/0009-0004-1880-9585)
- D. A. Kudlai
- D. A. Sergeev (ORCID: https://orcid.org/0009-0007-9699-233X)
- Alla V. Pavlova (ORCID: https://orcid.org/0000-0001-5881-9236)
Institutions
- Belgorod National Research University (RU)
- Sechenov University (RU)
- Novosibirsk State University (RU)
- Lomonosov Moscow State University (RU)
- Institute of Chemical Biology and Fundamental Medicine (RU)
- Novosibirsk Institute of Organic Chemistry (RU)
- Ministry of Health of the Russian Federation (RU)
- Siberian Branch of the Russian Academy of Sciences (RU)
- Medical Technologies (Czechia) (CZ)
Publication Details
- Journal
- Experimental and Clinical Gastroenterology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.31146/1682-8658-ecg-229-9-147-160
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00