Rapid Diagnostic Sequencing of Stool DNA Using Targeted Nanopore Sequencing in Patients With a Pulmonary Tuberculosis Diagnosis
Stool tNGS of <i>Mycobacterium tuberculosis</i> using nanopore technology provides a rapid and accurate method to inform the design of effective treatment regimens in patients with pulmonary tuberculosis in countries with high DR tuberculosis burdens and limited resources.
Authors
- Tanja Niemann (ORCID: https://orcid.org/0009-0009-6850-9579)
- Eric Bortz (ORCID: https://orcid.org/0000-0002-1376-0012)
- Alexander Kay (ORCID: https://orcid.org/0000-0001-5283-4697)
- Anna M. Mandalakas (ORCID: https://orcid.org/0000-0002-8091-3509)
- Clement Gascua Adu-Gyamfi (ORCID: https://orcid.org/0000-0002-3190-9343)
- Tara Ness (ORCID: https://orcid.org/0000-0002-4425-418X)
- Gugu Maphalala (ORCID: https://orcid.org/0000-0002-3635-8405)
- Christoph Lange (ORCID: https://orcid.org/0000-0002-9691-4741)
- Maia Madison (ORCID: https://orcid.org/0000-0001-9410-5150)
- Stefan Niemann (ORCID: https://orcid.org/0000-0002-6604-0684)
- Andrew R. DiNardo (ORCID: https://orcid.org/0000-0001-5990-6470)
- Viola Dreyer (ORCID: https://orcid.org/0000-0003-2997-3693)
- Durbbin Mulengwa (ORCID: https://orcid.org/0000-0003-0536-7859)
- Anca Vasiliù (ORCID: https://orcid.org/0000-0001-5336-7859)
- Doctor Busizwe Sibandze (ORCID: https://orcid.org/0000-0002-1331-3124)
- Nontobeko Maphalala (ORCID: https://orcid.org/0000-0001-9097-4631)
- Mangaliso Ziyane
- Sindisiwe Dlamini
- Abigail Seeger
- Wethusonkhe Khumalo
Institutions
- Radboud University Nijmegen (NL)
- University of Alaska Anchorage (US)
- Baylor College of Medicine (US)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Baylor College of Medicine Children’s Foundation (UG)
- German Center for Infection Research (DE)
- Amsterdam Institute for Global Health and Development (NL)
- Research Center Borstel - Leibniz Lung Center (DE)
- Children’s Foundation (GB)
- Texas Children's Hospital (US)
- Amsterdam University Medical Centers (NL)
- Ministry of Health (SZ)
- University of Amsterdam (NL)
- University of Lübeck (DE)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1093/ofid/ofaf121
- Citations
- 3
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Pediatric Infectious Diseases Society
- Deutsches Zentrum für Infektionsforschung
- Oxford Nanopore Technologies
- Changchun University of Science and Technology
- National Institutes of Health
- National Institute of General Medical Sciences