The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells

During peripheral nervous system development, Schwann cells undergo Rac1-dependent cytoskeletal reorganization as they insert cytoplasmic extensions into axon bundles to sort and myelinate individual axons. However, our understanding of the direct effectors targeted by Rac1 is limited. Here, we demonstrate that striatin-3 and MOB4 are Rac1 interactors. We show that Schwann-cell-specific ablation of striatin-3 causes defects in lamellipodia formation, and conditional Schwann cell knockout for striatins presents a severe delay in radial sorting. Finally, we demonstrate that deletion of Rac1 or striatin-1/3 in Schwann cells causes defects in the activation of Hippo pathway effectors YAP and TAZ and the expression of genes co-regulated by YAP and TAZ, such as extracellular matrix receptors. In summary, our results indicate that striatin-3 is a Rac1 interactor and that striatins are required for peripheral nervous system development and reveal a role for Rac1 in the regulation of the Hippo pathway in Schwann cells.

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Publication Details

Journal
Cell Reports
Published
2025-03-01
DOI
https://doi.org/10.1016/j.celrep.2025.115401
Citations
3
Primary Topic
Hippo pathway signaling and YAP/TAZ
Type
article
Field-Weighted Citation Impact
3.45

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article

The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells

Shreya Patel, Caterina Berti, Yannick Poitelon, Matthias Selbach et al.
3 citations
Cell Reports
Hippo pathway signaling and YAP/TAZ
3.45
article

The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells

Shreya Patel, Caterina Berti, Yannick Poitelon, Matthias Selbach, Fraser J. Sim, James C. French, M. Laura Feltri, Marilena Palmisano, Marta Pellegatta, Michael R. Weaver, Florian Paul, Sophie Belin, Edward J. Hurley, Dominika Shkoruta, Scott Ferguson
article en
3 citations

Abstract

During peripheral nervous system development, Schwann cells undergo Rac1-dependent cytoskeletal reorganization as they insert cytoplasmic extensions into axon bundles to sort and myelinate individual axons. However, our understanding of the direct effectors targeted by Rac1 is limited. Here, we demonstrate that striatin-3 and MOB4 are Rac1 interactors. We show that Schwann-cell-specific ablation of striatin-3 causes defects in lamellipodia formation, and conditional Schwann cell knockout for striatins presents a severe delay in radial sorting. Finally, we demonstrate that deletion of Rac1 or striatin-1/3 in Schwann cells causes defects in the activation of Hippo pathway effectors YAP and TAZ and the expression of genes co-regulated by YAP and TAZ, such as extracellular matrix receptors. In summary, our results indicate that striatin-3 is a Rac1 interactor and that striatins are required for peripheral nervous system development and reveal a role for Rac1 in the regulation of the Hippo pathway in Schwann cells.

Cell ReportsVol. 44(3)
Buffalo State University (US), Buffalo Society of Natural Sciences (US), Ivano-Frankivsk National Medical University (UA), Max Delbrück Center (DE), University at Buffalo, State University of New York (US), Albany Medical Center Hospital (US)
National Institute of Neurological Disorders and Stroke
Zero hunger
Openalex Percentile: Top 10%
Hippo pathway signaling and YAP/TAZ
3.45
DOIOpen Access PDFOpenAlex
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