SLC31A1 loss depletes mitochondrial copper and promotes cardiac fibrosis
A novel epigenetic mechanism was demonstrated through which copper deficiency increases mitochondrial copper depletion and impairs CF. Findings provide new insights for the development of preventive measures for CF.
Authors
- Hui Tao (ORCID: https://orcid.org/0000-0003-3761-8659)
- Jingjing Yang (ORCID: https://orcid.org/0000-0001-8521-7492)
- He Sun
- Zhiyan Liu (ORCID: https://orcid.org/0000-0001-9668-7756)
- Yan Shi (ORCID: https://orcid.org/0000-0003-4595-9349)
- Ji-Ming Sha (ORCID: https://orcid.org/0000-0001-7994-5282)
- Bin Tu
- Yang Zhou (ORCID: https://orcid.org/0000-0003-0453-4598)
- Kai Song (ORCID: https://orcid.org/0000-0001-6792-7159)
- Jian‐Yuan Zhao (ORCID: https://orcid.org/0000-0001-9861-0330)
- Li-Chan Lin
- Zeyu Zhou (ORCID: https://orcid.org/0000-0001-9357-6161)
- Zhang Ye (ORCID: https://orcid.org/0000-0003-3495-5596)
Institutions
- Shanghai Jiao Tong University (CN)
- Anhui Medical University (CN)
- XinHua Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1093/eurheartj/ehaf130
- Citations
- 23
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 25.75
Funders
- National Natural Science Foundation of China