Isoflavone Constituents of the Underground Parts of <i>Iris florentina</i> and Their Inhibitory Activity on the Formation of Advanced Glycation End Products
Two new isoflavone glucosides, irisolone 4'-O-[O-β-d-glucopyranosyl-(1→6)-O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranoside] (1) and iriskashmirianin 4'-O-[O-β-d-glucopyranosyl-(1→6)-O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranoside] (2) were isolated from the underground parts of Iris florentina (Iridaceae). The structures of 1 and 2 were determined based on extensive spectroscopic data analyses and hydrolytic cleavage results. The isoflavone derivatives previously isolated from this plant were evaluated for their ability to inhibit the formation of advanced glycation end products.
Authors
- Nana Fujita
- Yuka Yoshizawa
- Akihito Yokosuka (ORCID: https://orcid.org/0000-0002-3363-905X)
- Yoshihiro Mimaki (ORCID: https://orcid.org/0000-0001-7940-5673)
Institutions
- Tokyo University of Pharmacy and Life Sciences (JP)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1248/cpb.c24-00776
- Citations
- 2
- Primary Topic
- Phytoestrogen effects and research
- Type
- article
- Field-Weighted Citation Impact
- 2.94