Gut microbiome modulates the outcome in primary central nervous system lymphoma patients undergoing chemotherapy: An ancillary study from the BLOCAGE trial
Our findings suggest that gut microbiome communities modulate clinical outcomes in PCNSL patients undergoing standard treatment. Moreover, after future validation in external cohorts, the quantification of Parabacteroides distasonis could potentially provide a basis for patient stratification and guide personalized therapeutic strategies in the near future.
Authors
- Khê Hoang‐Xuan (ORCID: https://orcid.org/0000-0003-4072-1999)
- Sylvain Choquet (ORCID: https://orcid.org/0000-0002-7791-0470)
- Yah-se Abada (ORCID: https://orcid.org/0000-0003-0085-8747)
- Laura Rozenblum (ORCID: https://orcid.org/0000-0002-6306-8008)
- Eva Kirasic
- Agustí Alentorn (ORCID: https://orcid.org/0000-0002-7220-2686)
- Lucia Nichelli (ORCID: https://orcid.org/0009-0006-0934-5365)
- Bertrand Mathon (ORCID: https://orcid.org/0000-0002-9182-5846)
- Karima Mokhtari (ORCID: https://orcid.org/0000-0002-4777-7584)
- Élise Sourdeau
- Caroline Houillier (ORCID: https://orcid.org/0000-0003-2931-7522)
- Noemie Barillot
- Isaias Hernández-Verdín (ORCID: https://orcid.org/0000-0001-6295-2507)
- Aurélie Kas (ORCID: https://orcid.org/0000-0001-9463-3658)
- Lucas Rincón de la Rosa (ORCID: https://orcid.org/0009-0001-4863-2088)
- Magali Le Tarff-Tavernier
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
- Institut du Cerveau (FR)
- Hôpital Charles-Foix (FR)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1093/neuonc/noaf059
- Citations
- 3
- Primary Topic
- Cancer survivorship and care
- Type
- article
- Field-Weighted Citation Impact
- 3.14