CORRELATION OF INTERLEUKIN-33 WITH SOME BIOCHEMICAL VARIABLES IN CHRONIC HEPATITIS B PATIENTS IN AL-FALLUJAH CITY

Hepatitis B virus (HBV) disease is one of the main reasons of cirrhosis, chronic hepatitis, eventually hepatocellular carcinoma (HCC); as a result, it can be extremely harmful to the liver. Main goal of this paper to explore the correlation of interleukin (IL) 33with certain biochemical parameters in Iraqi patients’ with chronic hepatitis B (CHB). This research included 40 CHB patients from Al- Fallujah city and 40 healthy controls (HCs). The serum concentration of IL-33 was established using an enzyme linked immunosorbent assay (ELISA), while the ratio of waist to thoracic (W/T), waist to neck (W/N), waist to hip (W/H), systolic blood pressure (SBP), diastolic blood pressure (DBP), and rate of pulses (ROP) were carefully measured and documented. IL-33, was discovered to be increased in CHB patients in comparison to HCs (P<0.000l), BMI, W/T were higher in CHB patients compared to HCs with (P<0.05), also age, W/N, W/H, DBP and ROP were greater in patients with CHB in comparison to HCs, while SBP was greater in HCs than in CHB with (P > 0.05) for these parameters, there was a weak positive correlation between IL-33 with BMI (r=0.254, P= 0.028), other studied variables, did not show significant correlation with IL-33 which gave the following results DBP (r=0.182, P=0.119), W/N(r=0.0170, P=0.885), ROP (r = 0.103, P = 0.379), Age (r = 0.048, P = 0.675), W/T (r = 0.017, P = 0.885) , SBP (r = -0.045, P = 0.704) and W/H (r = -0.081, P = 0.492), respectively. Serum IL-33 levels can be used in the detection of CHB and may be an effective biomarker in the diagnostic test of CHB.