Effects of hypoxia stress on the milk synthesis in bovine mammary epithelial cells
Hypoxia alters milk synthesis in BMECs by disrupting milk protein synthesis, enhancing lipid metabolism, and impairing energy production. These findings provide valuable insights into the molecular mechanisms underlying the effect of oxygen deprivation on lactation efficiency, offering potential targets for mitigating hypoxic stress in the mammary glands of dairy animals.
Authors
- Lizhu Fang
- Feng‐Qi Zhao (ORCID: https://orcid.org/0000-0003-4926-670X)
- Hongyun Liu (ORCID: https://orcid.org/0000-0001-8806-6204)
- Zhuolin Liu (ORCID: https://orcid.org/0000-0001-8897-1685)
- Ziyan Yang (ORCID: https://orcid.org/0009-0006-0378-0462)
- Ye Jin (ORCID: https://orcid.org/0009-0006-6445-9955)
Institutions
- University of Vermont (US)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s40104-025-01174-0
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Agriculture Research System of China