Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome
Circulating miRNAs 223-3p and 378c were associated with the risk of HHF/CVD after adjustment for clinical factors and established cardiovascular biomarkers. Carrier-specific measurement of these miRNAs may emerge as novel minimally invasive biomarkers for post-ACS cardiac remodeling and shed light on potentially new targetable pathways.
Authors
- Worawan B. Limpitikul (ORCID: https://orcid.org/0000-0001-6171-9906)
- Jeong‐Gun Park (ORCID: https://orcid.org/0000-0003-4615-1747)
- Nedyalka Valkov (ORCID: https://orcid.org/0000-0003-3947-9947)
- Ravi V. Shah (ORCID: https://orcid.org/0000-0002-4471-7156)
- Michael G. Silverman (ORCID: https://orcid.org/0000-0002-5885-1866)
- Saumya Das (ORCID: https://orcid.org/0000-0002-4521-4606)
- Elizabeth Hutchins (ORCID: https://orcid.org/0000-0003-2543-0798)
- Marta García-Contreras (ORCID: https://orcid.org/0000-0001-8014-7966)
- Marc S. Sabatine (ORCID: https://orcid.org/0000-0002-0691-3359)
- Eric B. Alsop (ORCID: https://orcid.org/0000-0002-2717-7573)
- James Louis Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
- Ashish Yeri
- Anthony Rosenzweig (ORCID: https://orcid.org/0000-0001-6387-0386)
- David A. Morrow (ORCID: https://orcid.org/0000-0002-9589-5382)
- Priyanka Gokulnath (ORCID: https://orcid.org/0000-0003-2813-330X)
- Michail Spanos (ORCID: https://orcid.org/0000-0003-1205-4201)
- Raymond Y. Kwong (ORCID: https://orcid.org/0000-0001-8212-0759)
- Fernando Camacho Garcia
- Claire Lin (ORCID: https://orcid.org/0009-0006-7201-7567)
- Guoping Li (ORCID: https://orcid.org/0000-0002-0134-2593)
- Kendall Jensen
- Kriti Bomb
Institutions
- Brigham and Women's Hospital (US)
- Translational Genomics Research Institute (US)
- Massachusetts General Hospital (US)
- Stanley Medical Research Institute (US)
- Baim Institute for Clinical Research (US)
- Thrombolysis in Myocardial Infarction Study Group (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Extracellular Vesicle
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1016/j.vesic.2025.100070
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61