Melanophilin inhibit the growth and lymph node metastasis of triple negative breast cancer via the NONO-SPHK1-S1P axis
This study preliminarily elucidated a mechanism underlying lymph node metastasis in TNBC and identified the role of the MLPH-NONO-SPHK1-S1P axis in regulating proliferation and lymph node metastasis in TNBC. These findings may help design strategies for predicting and treating metastasis in TNBC.
Authors
- Qingchuan Chen (ORCID: https://orcid.org/0000-0001-8371-4225)
- Xing Yao (ORCID: https://orcid.org/0000-0003-2761-3221)
- Tiffany Yuen
- Jianjun Zhang (ORCID: https://orcid.org/0000-0002-7069-5771)
- Liu Ye-fu
- Shulan Sun
Institutions
- University of Electronic Science and Technology of China (CN)
- Dalian University of Technology (CN)
- Sichuan Cancer Hospital (CN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s12967-025-06240-9
- Citations
- 1
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Liaoning Province
- National Natural Science Foundation of China-Liaoning Joint Fund