Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

Targeted metabolomics was conducted on plasma samples from a nested case-cohort study within the biracial REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. This longitudinal study investigates health outcomes with a focus on stroke disparities across the United States, particularly in the Southeastern "Stroke Belt," where stroke risk and mortality are 2-4 times higher in the Black population. The REGARDS study recruited 30,239 Black and White participants aged 45 years or older. This dataset includes 2,377 baseline plasma samples collected between 2003 and 2007 from a stroke case-cohort sub-study, with 1,056 randomly selected cohort participants and 1,321 stroke cases. The resulting data provides a resource for investigating metabolic profiles and their potential implications for health outcomes and disparities.

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Publication Details

Journal
Scientific Data
Published
2025-03-06
DOI
https://doi.org/10.1038/s41597-025-04746-x
Primary Topic
Neurological Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

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Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

Zsuzsanna Ament, Mary Cushman, Varun Bhave, Marguerite R. Irvin, Ana‐Lucia Garcia Guarniz, Amit Patki, Suzanne E. Judd, Naruchorn Kijpaisalratana, Catharine A. Couch, W. Taylor Kimberly
article en

Abstract

Targeted metabolomics was conducted on plasma samples from a nested case-cohort study within the biracial REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. This longitudinal study investigates health outcomes with a focus on stroke disparities across the United States, particularly in the Southeastern "Stroke Belt," where stroke risk and mortality are 2-4 times higher in the Black population. The REGARDS study recruited 30,239 Black and White participants aged 45 years or older. This dataset includes 2,377 baseline plasma samples collected between 2003 and 2007 from a stroke case-cohort sub-study, with 1,056 randomly selected cohort participants and 1,321 stroke cases. The resulting data provides a resource for investigating metabolic profiles and their potential implications for health outcomes and disparities.

Scientific DataVol. 12(1)
University of Vermont (US), Harvard University (US), Chulalongkorn University (TH), University of Alabama at Birmingham (US), Massachusetts General Hospital (US), Center for Systems Biology (US)
National Institute of Neurological Disorders and Stroke
Gender equality
Openalex Percentile: Top 94%
Neurological Disease Mechanisms and Treatments
DOIOpen Access PDFOpenAlex
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