Multi-omics analysis of synovial tissue and fluid reveals differentially expressed proteins and metabolites in osteoarthritis
Alterations in energy metabolism, cartilage repair, and osteogenic mechanisms are critical. The related metabolites and proteins have potential as diagnostic and therapeutic targets for osteoarthritis.
Authors
- Tianhao Xu (ORCID: https://orcid.org/0000-0002-9154-0250)
- Kaibo Zhang (ORCID: https://orcid.org/0000-0002-0732-9218)
- Weili Fu (ORCID: https://orcid.org/0000-0003-4438-2760)
- Meng Gong (ORCID: https://orcid.org/0000-0002-1203-5820)
- Minghao Ge
- Jian H. Li (ORCID: https://orcid.org/0000-0003-0376-0702)
- Weihao Sun (ORCID: https://orcid.org/0009-0005-8114-8481)
- Runze Yang (ORCID: https://orcid.org/0000-0002-1192-9363)
- Zhiwei Zhao (ORCID: https://orcid.org/0009-0008-9893-7411)
Institutions
- Peking University (CN)
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- Beijing Jishuitan Hospital (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s12967-025-06310-y
- Citations
- 15
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 25.02
Funders
- National Natural Science Foundation of China
- Sichuan Province Science and Technology Support Program
- West China Hospital, Sichuan University