Impact of celastrol on mitochondrial dynamics and proliferation in glioblastoma
Celastrol promotes mitochondrial fission in glioblastoma multiforme cells by reducing mitofusin-1 expression, accompanying mitochondrial dysfunction, lower mitochondrial membrane potential, heightened oxidative stress, and decreased Cyclin-dependent kinase 1 and Cyclin B1 levels. This indicates that Celastrol possesses potential for repurposing as an agent targeting mitochondrial dynamics in glioblastoma multiforme, warranting further investigation.
Authors
- Junzhao Sun (ORCID: https://orcid.org/0000-0001-6624-2350)
- Baorui Guo
- Wenying Lv (ORCID: https://orcid.org/0000-0002-7329-7066)
- Hanbo Zhang (ORCID: https://orcid.org/0000-0002-2235-6855)
- Yanteng Li (ORCID: https://orcid.org/0000-0003-0613-8898)
- Mou Gao (ORCID: https://orcid.org/0009-0000-1058-1169)
- Lei Liang (ORCID: https://orcid.org/0000-0002-5397-0284)
- Jianning Zhang (ORCID: https://orcid.org/0000-0002-5516-4753)
- Jiayu Liu (ORCID: https://orcid.org/0000-0001-5086-5502)
- Ning Liu (ORCID: https://orcid.org/0000-0001-9023-4254)
- Shengqiang Xie
- Gang Cheng
- Jilong Hei
- Jiangting Wang
Institutions
- Shanxi Medical University (CN)
- Chinese PLA General Hospital (CN)
- Xiangyang Central Hospital (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s12885-025-13733-9
- Citations
- 3
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 7.14