Proinflammatory macrophages release CXCL5 to regulate T cell function and limit effects of αPD-1 in steatosis-driven liver cancer
In this study, we investigated the role of CXCL5 in the progression from steatosis to liver cancer. We uncovered a novel inhibitory role of CXCL5 in T cell recruitment, with implications for NAC-targeted therapy and immune checkpoint synergy in liver cancer. We believe our findings will be of interest to physicians, researchers, and patients interested in therapeutic development and translational research in liver disease.
Authors
- Keigo Machida (ORCID: https://orcid.org/0000-0002-9721-8553)
- Genshu Wang
- Taojian Tu
- Anthony B. El-Khoueiry (ORCID: https://orcid.org/0000-0002-9053-3841)
- Brittney Hua
- Liyun Yuan (ORCID: https://orcid.org/0000-0001-9122-6782)
- Tianyi Xia (ORCID: https://orcid.org/0000-0001-9341-7742)
- Karam Ashouri (ORCID: https://orcid.org/0009-0000-1825-1033)
- Enrique Cadenas (ORCID: https://orcid.org/0000-0001-5199-2423)
- Whitaker Cohn (ORCID: https://orcid.org/0000-0001-9198-8904)
- Shefali Chopra (ORCID: https://orcid.org/0000-0003-3611-626X)
- Julian P. Whitelegge (ORCID: https://orcid.org/0000-0003-2763-7733)
- Mario Alba (ORCID: https://orcid.org/0000-0002-0587-8790)
- Bangyan L. Stiles (ORCID: https://orcid.org/0000-0001-5480-2074)
- Curtis T. Okamoto (ORCID: https://orcid.org/0000-0001-8700-858X)
- Zhang‐Xu Liu (ORCID: https://orcid.org/0000-0001-7290-3506)
- Weiming Yuan (ORCID: https://orcid.org/0000-0002-4780-7157)
- Handan Hong
- Christina Nakhoul
- Diala Alhousari
- Lina He
- Yiwei Gu
- Guirong Xu (ORCID: https://orcid.org/0000-0002-8127-1173)
- Qi Tang (ORCID: https://orcid.org/0000-0002-5196-5932)
- Anastasia Martynova
- Phat Ky Nguyen (ORCID: https://orcid.org/0000-0002-1309-6780)
Institutions
- University of Southern California (US)
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Neurobehavioral Systems (US)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101385
- Citations
- 6
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 6.27