Embryonic lethal abnormal vision like 1-stabilized histone deacetylase 6 promotes hepatic stellate cell activation to accelerate liver fibrosis progression through ribosomal protein S5 downregulation
Our data revealed that ELAVL1-stabilized HDAC6 promoted TGF-β1-induced HSC activation by repressing RPS5 acetylation, thus providing a novel target for alleviating LF progression.
Authors
- Yiwen Qiu (ORCID: https://orcid.org/0000-0003-0022-4824)
- Qin Wang (ORCID: https://orcid.org/0000-0002-1079-5914)
- Jianping Wang (ORCID: https://orcid.org/0000-0002-6596-8771)
- Cheng Yan (ORCID: https://orcid.org/0000-0002-4909-439X)
- Wenjie Zhang (ORCID: https://orcid.org/0000-0001-6457-7800)
- Li Zhang (ORCID: https://orcid.org/0000-0002-7606-6642)
Institutions
- Northwest Minzu University (CN)
- Hainan University (CN)
- Hainan Agricultural School (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2025-03-06
- DOI
- https://doi.org/10.25259/cytojournal_221_2024
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00