Electroacupuncture Inhibits NLRP3-Mediated Microglial Pyroptosis to Ameliorate Chronic Neuropathic Pain in Rats
These findings demonstrate the EA ameliorates the neuroinflammation and pyroptosis to relieve chronic NP by suppressing NLRP3 inflammasome activation in microglia. EA may serve as a viable treatment therapy for chronic NP.
Authors
- Shuyi Kong (ORCID: https://orcid.org/0000-0003-0416-5323)
- Zhen Gu
- Wenyun Kui
- Lingxing Li (ORCID: https://orcid.org/0000-0001-8323-7369)
- Kaiqiang Wang (ORCID: https://orcid.org/0000-0002-3031-599X)
- Yanan Li (ORCID: https://orcid.org/0000-0002-3134-7045)
- Jun Qing Yu (ORCID: https://orcid.org/0000-0001-5008-2153)
- Lei Xie (ORCID: https://orcid.org/0000-0001-9140-8105)
- Chunchun Xue
- Aiping Huang (ORCID: https://orcid.org/0000-0002-6354-9039)
- Lilong Song
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/jpr.s506569
- Citations
- 9
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 7.25