Enhanced efficacy of dual chimeric antigen receptor-T cells targeting programmed death-ligand 1 and cancer-associated fibroblasts in colorectal cancer <i>in vitro</i>

This study successfully developed dual-targeted CAR-T cells against PD-L1 and CAF and demonstrated their superior antitumor activity and immunomodulatory effects on CRC treatment. This novel therapeutic strategy was established using CAR T-cell technology for the treatment of CRC.

Authors

Chunxiong Luo (ORCID: https://orcid.org/0000-0001-8974-7693)
Qin Xie (ORCID: https://orcid.org/0009-0004-8614-3711)
Han He (ORCID: https://orcid.org/0009-0004-8632-3325)
Yang Gao (ORCID: https://orcid.org/0000-0001-6513-2926)
Jidong Miao
Hua Yang
Jiawei Li (ORCID: https://orcid.org/0000-0001-9957-8192)

Institutions

Zigong First People's Hospital (CN)

Publication Details

Journal: CytoJournal
Published: 2025-03-06
DOI: https://doi.org/10.25259/cytojournal_245_2024
Citations: 4
Primary Topic: CAR-T cell therapy research
Type: article
Field-Weighted Citation Impact: 4.18

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article

Enhanced efficacy of dual chimeric antigen receptor-T cells targeting programmed death-ligand 1 and cancer-associated fibroblasts in colorectal cancer in vitro

Chunxiong Luo, Qin Xie, Han He, Yang Gao et al.

Mar 6, 2025

4 citations

CytoJournal

CAR-T cell therapy research

4.18

article

Enhanced efficacy of dual chimeric antigen receptor-T cells targeting programmed death-ligand 1 and cancer-associated fibroblasts in colorectal cancer in vitro

Chunxiong Luo, Qin Xie, Han He, Yang Gao, Jidong Miao, Hua Yang, Jiawei Li

March 6, 2025article en

4 citations

Abstract

This study successfully developed dual-targeted CAR-T cells against PD-L1 and CAF and demonstrated their superior antitumor activity and immunomodulatory effects on CRC treatment. This novel therapeutic strategy was established using CAR T-cell technology for the treatment of CRC.

CytoJournalVol. 22

Zigong First People's Hospital (CN)

Openalex Percentile: Top 6%

CAR-T cell therapy research

4.18

DOI Open Access PDF OpenAlex

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